The World of Afro Samurai is set in a neo feudal world where gunpowder guns and melee weapons such as swords are in common use and futuristic technology such as computers, cybernetic technology, RPG Launchers and Flame Thrower's, advanced binoculars, Turn Table's, Robotic's as seen with Machine Ninja's and the Afro Droid, energy weapon's and motorcycles and even bio technology/cloning.

The locations seen so far seem to be based in Japan and the architecture seems to be Japanese themed. Also countries or parts of the world seem to be called by direction for example Soshun claims to be from The West which was a name of Europe called The Western World.

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